Specialty GenesΒΆ

Specialty Genes

Specialty Genes refers to genes that are of particular interest to infectious disease researchers, such as virulence factors, antibiotic resistance genes, drug targets, and human homologs. For each class, reference genes are collected from reputed external databases or manually curated by the PATRIC team and then mapped to their homologs based on sequence similarity using BLASTP. For more details, see Specialty Genes. We also provide a data summary targeted specifically to Antibiotic Resistance Data.

What do we mean by ...


Antibiotic Resistance:

Antibiotic Resistance refers to the ability of bacteria to develop resistance to antibiotics through gene mutation or acquisition of antibiotic resistance genes. We have integrated and mapped known antibiotic resistance genes from the following sources:

CARD
NDARO

Drug Targets:

Drug Targets refer to the proteins being targeted by known/approved/experimental small molecule drugs. We have integrated and mapped such drug targets from the following sources:

DrugBank
TTD

Essential Genes:

Essential genes refer to the genes that are critical for the organism's survival. We havve conducted a flux-balance analysis for reference and representative genomes in PATRIC and mapped essential genes.


Human Homologs:

Human Homologs refer to the bacterial proteins that share high sequence similarity with human proteins. We have integrated and mapped proteins from Reference Human Genome at NCBI.


Transporters:

Transporters refer to proteins that serve the function of moving other materials within an organism. We have integrated and mapped proteins from Transporter Classification Database.


Virulence Factors:

Virulence factors refer to the gene products that enable bacteria to establish itself on or within a host organism and enhance its potential to cause disease. We have integrated and mapped virulence factor genes from the following sources:

PATRIC_VF
VFDB
Victors

How Do We Curate, Integrate, and Map Specialty Genes?

How Do We Curate, Integrate, and Map Specialty Genes?